Cade, W. Todd, PT, PhD BIOGRAPHICAL SKETCH B.S., University of Maryland, College Park, 1991 M.Sc., University of Miami, Florida, 1994 Ph.D., University of Maryland, Baltimore, 2002 CLINICAL INTERESTS Nutritional and exercise interventions for metabolic diseases including HIV-related metabolic syndrome (HIV-MS, (also called HIV-Lipodystrophy), Type 2 diabetes mellitus (T2DM); obesity/metabolic syndrome (MS), adult and pediatric skeletal and cardiomyopathy (e.g. Barth Syndrome) and in pregnancy. RESEARCH INTERESTS Mechanisms and treatments (nutritional/exercise/pharmaceutical) for whole body and myocardial substrate (e.g. amino acid, glucose, fatty acid) metabolism abnormalities in metabolic diseases such as HIV-MS, T2DM, obesity/MS and adult and pediatric skeletal and cardiomyopathy (e.g.. Barth Syndrome). I am also interested in the effect of nutrient metabolism during pregnancy on in utero development and childhood metabolic disease. REPRESENTATIVE PUBLICATIONS BOOK CHAPTERS Cade WT and Yarasheski KE. “Molecular Aspects of Sarcopenia and Aging”. Principles of Molecular Medicine. 2006, 2nd Edition. Editors: Runge MS & Patterson WC. Humana Press Inc., Totowa, NJ JOURNAL Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, and Ramanadham S. Protease Inhibitors used in the Treatment of HIV+ Induce -cell Apoptosis via the Mitochondrial Pathway and Compromise Insulin Secretion Am J Physiol Endocrinol Metab (February 10, 2009). doi:10.1152/ajpendo.90445.2008 Cade WT. Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting. Phys Ther. 2008 Nov;88(11):1322-35. Epub 2008 Sep 18. Schambelan M, Wilson PW, Yarasheski KE, Cade WT, Dávila-Román VG, D'Agostino RB Sr, Helmy TA, Law M, Mondy KE, Nachman S, Peterson LR, Worm SW; for Working Group 5. Development of Appropriate Coronary Heart Disease Risk Prediction Models in HIV-Infected Patients. Circulation. 2008 Jun 19. [Epub ahead of print]. Mutimura E, Stewart A, Crowther N & Cade WT. The Cardiometabolic Syndrome in the Developing World: An African Perspective. J CardioMet Synd 2008 Spring;3(2):106-110. Cade WT. Left Ventricular Dysfunction in HIV. J CardioMet Synd 2008 Spring;3(2):83-7. Cade WT & Yarasheski JE. Cardiometabolic Disease in the Human Immunodeficiency Virus: The Tip of the Iceberg? J CardioMet Synd 2008 Spring;3(2):77-8. Mutimura E, Stewart A, Crother N, Yarasheski KE, & Cade WT. The Effects of Exercise Training on Quality of Life in HAART-Treated HIV-Positive Rwandan Subjects with Body Fat Redistribution. Qual Life Res Apr;17(3):377-85. Epub 2008 Mar 5. Mutimura E, Crother N, Cade WT, Yarasheski KE, & Stewart A,. Exercise training reduces central adiposity and improves metabolic indices in HAART-treated HIV-infected subjects in Rwanda: a randomized controlled trial. AIDS Res Hum Retroviruses. 2008 Jan;24(1):15-23. Carper MJ, Cade WT, Cam M, Zhang S, Shalev A, Yarasheski KE, & Ramanadham S. HIV-Protease Inhibitors Induce Expression of Suppressor Cytokine Signaling-1 in Insulin-Sensitive Tissues and Promote Insulin Resistance and Type 2 Diabetes. Am J Physiol Endocrinol Metab, 2008, Jan 2 [Epub ahead of print]. Cade WT, Reeds DN, Davila-Roman VG, Waggoner AN, Lasso-Claxton S, Powderly WG, & Yarasheski KE. Post-Exercise Heart Rate Recovery in HIV+ Subjects Taking HAART: Indicator of Early CVD? HIV Med, 2007, Dec 12 [Epub ahead of press]. Cade WT, Reeds DN, Mittendorfer B, Patterson BW, Powderly WG, Klein S, & Yarasheski, KE. Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E812-9. Epub 2006 Nov 14. Reeds DN, Cade WT, Patterson BW, Powderly WG, Klein S, Yarasheski, KE. Whole body proteolysis rate is elevated in HIV-associated insulin resistance. Diabetes, 2006 Oct;55(10):2849-55. Subramanian S, DeRosa MA, Bernal-Mizrachi C, Laffely N, Cade WT, Yarasheski KE, Cryer PE, & Semenkovich CF. PPARα activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans. Am J Physiol Endocrinol Metab,July 25; [Epub ahead of print]. Reeds DN, Yarasheski KE, Fontana L, Cade WT, Laciny E, Demoss A, Patterson BW, Powderly WG, and Klein S. Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. Am J Physiol Endocrinol Metab2006; (1)E47-E53. Cade, WT, Peralta, L, and Keyser, RE. Aerobic Exercise Dysfunction in HIV: A Potential Link to Physical Disability. Physical Therapy 2004; 84: 655-664. Cade WT, Nabar SR, Keyser RE. Reproducibility of the Exponential Rise Technique of CO2 Rebreathing for Measuring PVCO2 and CVCO2 to Non-Invasively Estimate Cardiac Output During Incremental, Maximal Treadmill Exercise. Eur J of Appl Physiol 2004; 91:669-76. Cade WT, Fantry LE, Nabar SR, Shaw DK, Keyser RE. Impaired Oxygen On-Kinetics in Individuals with HIV. Arch Phys Med Rehabil 2003; 84: 1831-1838. Cade WT, Fantry LE, Nabar SR, Keyser RE. Decreased Arteriovenous Oxygen Difference During Treadmill Testing in Individuals Infected with HIV. Arch Phys Med Rehabil 2003; 84:1595-1603. Cade WT, Fantry LE, Nabar SR, Shaw DK, Keyser RE. A Comparison of Qt and a-vO2 in Individuals with HIV Taking and Not Taking HAART. Med Sci Sport Exer 2003; 35(7): 1108-1117. Cade WT, Peralta L, Keyser RE. Aerobic Capacity in Adolescents with HIV and Controls. Pediatri Rehabil 2002; 5(3): 161-69. Keyser RE, Rus V, Cade WT, Kalappa N, Flores RH, Handwerger, BS. Evidence for Aerobic Insufficiency in Women with Systemic Lupus Erythmatosus. Arthritis Care Res 2003; 49(1): 16-22. Keyser RE, Peralta L, Cade WT, Miller S, Anxist J. Functional Aerobic Impairment in Adolescents Seropositive for HIV: A Quasi-Experimental Design. Arch Phys Med Rehabil 2000; 84: 1479-84. TEACHING RESPONSIBILITIES Bioenergetics (Ph.D in Movement Science and Post-Professional DPT)-course coordinator PROFESSIONAL ACTIVITIES Editorial Board Member, American Physical Therapy Association; Member, American Diabetes Association; Member, American Physiological Society, Member, International AIDS Society; Reviewer: J. of the Am. Med. Assoc, Am J of Physiology-Endocrinology and Metabolism, Journal of Clinical Endrocrinology, The J of the International AIDS Society, The J of the Acquired Immune Deficiency Syndromes, J of Infectious Disease, Medicine and Science in Sports and Exercise, Physical Therapy and AIDS Research and Retroviruses CONTACT INFORMATION W. Todd Cade, PT, PhD Assistant Professor Program in Physical Therapy and Internal Medicine Washington University in St. Louis-School of Medicine Campus Box 8502 4444 Forest Park Boulevard St Louis, MO 63108-2212 Office: (314) 286-1432 FAX: (314) 286-1410 Email address: tcade@wustl.edu