The focus of our research is the influence of physical activity and exercise on cardiorespiratory fitness and long-term health outcomes in various populations.

This research involves collaborations with investigators both within and outside of Washington University School of Medicine, as well as with community partners in St. Louis. These collaborative activities encompass investigations of novel cardiac rehabilitation programs, long-term calorie restriction among healthy adults as a strategy to modulate aging, longitudinal assessments of aerobic capacity among adults with heart failure, and novel nutrition-based therapies to improve aerobic capacity in patients with heart failure

BMI-for-age graphs showing cross-sectional BMI data for 3900 female students (A) and 4000 male students (B) attending the St. Louis Public Schools. Each symbol represents the BMI value of a single student. Ref: Racette et al. BMC Pediatrics (2017) 17:130.

Faculty Investigators

Susan B. Racette, PhD [Profile ]
Marghuretta Bland, PT, PhD [Profile ]
Alejandra Camacho-Soto, MD [Profile ]

Trainees, Students, and Staff Members

Lauren Park. PhD – Postdoctoral Fellow
Clifton Holmes, PhD, CSCS – Postdoctoral Fellow
Valene Garr Barry, PhD – Postdoctoral Fellow
Fatima Lakhani, MD – Medicine Resident
Chao Cao, MS – PhD Student
Nidhi Talpade – DPT Student
Tessa Roberts – DPT Student
Shauna Montoya – DPT Student
Christine Gordon, Research PT

Current Research Studies

Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging
Funding Source: R01 AG071717 (MPI: Das SK, Racette SB, Redman LR – Tufts University, WUSM, and Pennington Biomedical Research Center)

Enhancing Physical Function after COVID-19 among the Underserved
Funding Source: Foundation for Barnes-Jewish Hospital (PI: Racette SB)

Personalizing Exercise for Parkinson’s Disease
Funding Source: Foundation for Barnes-Jewish Hospital (PI: Racette SB)
ClinicalTrials.gov Link: https://clinicaltrials.gov/ct2/show/NCT04782518

Intensive Cardiac Rehabilitation with the Pritikin Program (PI: Peterson LR)

Heart Disease and Aerobic Capacity Registry
Funding Source: Foundation for Barnes-Jewish Hospital (co-PIs: Peterson LR and Racette SB)

Enhancing the CALERIE Network to Advance Aging Biology
Funding Source: R33 AG070455 (PI: Huffman K – Duke University School of Medicine)

Modified Application of Cardiac Rehabilitation (CR) for Older Adults (MACRO)
Funding Source: R01 AG060499 (PI: Forman DE – University of Pittsburgh)

Mind Your Heart Intervention for American Indian Women
Funding Source: R34 HL158947-01 (PI: Brooks JL – UNC Chapel Hill)

PRIDE Summer Institute in Cardiovascular Disease Comorbidities, Genetics, and Epidemiology (CVD-CGE)
Funding Source: R25 HL105400 (co-PIs: Rao DC and Dávila-Román VG)

Searching for Missing Heritability for Cardiometabolic Outcomes by Race
Funding Source: K01 HL127278 (PI: Hardy DS – Morehouse School of Medicine)

Home-Based Cardiac Rehabilitation (HCR) in the Time of COVID-19
Funding Source: Foundation for Barnes-Jewish Hospital (PI: Rich MW)

Past Research Studies

Intensive cardiac rehabilitation (ICR) with the Pritikin program: tolerability and effectiveness (Foundation for Barnes-Jewish Hospital, PI: Peterson LR)

Benefits of Intensive Cardiac Rehabilitation for Patients with Heart Failure with Reduced Ejection Fraction
Funding Source: Foundation for Barnes-Jewish Hospital (PI: Peterson LF)

The Inorganic Nitrate for Exercise in Heart Failure (iNIX-HF) trial
Funding Source: R34 HL138253 (PI: Peterson LR)

Caloric Restriction and Aging in Humans (U01 AG20487, PI: Holloszy JO)

AIM for Fitness (U.S. Department of Education; collaboration with the Saint Louis Public Schools)

Obesity Surveillance in St. Louis (City of St. Louis Department of Health, PIs: Racette SB and Clark BR)Nourishing an Urban Community (Washington University Institute for Public Health and St. Louis Regional Health Commission – St. Louis Community/University Health Research Partnership, PI: Racette SB)